Citicoline, also known as CDP-Choline, was originally developed in Japan in the 1960s to help support brain related disorders linked to poor circulation. Derived from choline and cytidine, it's a naturally occurring compound in the body and plays a critical role in brain health, specifically in the synthesis of phosphatidylcholine, a major component of brain tissues. As research on this compound expanded, its use spread to Europe and then globally as a dietary supplement for enhancing brain function, supporting memory, and maintaining overall brain health.