I have a form of histamine intolerance in which there are genetic mutations in my DAO and HNMT enzymes, leading to a slower clearance of histamine and allergic reactions upon ingestion of histamine rich foods. Taking one of these shortly before a meal eliminates most of the symptoms. I avoid the worst offenders (ex sauerkraut, cured meats) but other than that I am now able to eat freely with, at worst, mild easily tolerable symptoms. I experimented with higher doses, going up to 3 per meal (6 per day). While my histamine symptoms went from mild to zero, my depression significantly worsened, and I had a constant mild stomach ache. As another review mentioned, this pea DAO enzyme may break down precursors to neurotransmitters like serotonin and dopamine at higher doses, which could worsen depression. Upon lowering the dose back to 1-2 per day, the side effects went away within a few days. Overall, it's a great help for my histamine intolerance, just watch out for worsening of depression. Read more

Well it took me more time than ever to find a "non-porcine" DAO enzyme that actually works and these are a must for anyone with autoimmune issues like; MCAS, histamine intolerance, SIBO... Lyme, etc. They are not cheap, but they do help me out considerably when I am in reactive mode. I am NOT a doctor, but a overcomer of all of the above. Read more

UPDATE: Even though I could not take this product and it was not returnable, THE SELLER OFFERED A FULL REFUND. I HIGHLY RECOMMEND BUYING THE PRODUCT IF YOU HAVE NO ALLERGIES TO IT. I ordered late at night in need to get product to block an overload of histamine. It was my fault I overlooked it has microcrystalline cellulose which is usually from acacia. I am severely allergic to this plant/tree and have to beware of it in all meds and supplements. I hate it is non returnable when the protective film still in place. Had to trash it. Read more

I don’t normally leave reviews but I feel the need to share my experience. For many years I have suffered from strange symptoms like brain fog, joint pain, low energy, and in the last 7 years, rosacea. I have had many tests run and tried everything you can imagine to try and get rid of the rosacea. Recently, I came across some information on a link between rosacea and high histamine levels/low DAO in the body. All I could think was this is me! I started researching and decided to give a DAO supplement a shot along with a low histamine diet. From the very first pill, I noticed an immediate difference after I ate. Used to, I hated eating breakfast because I always felt bad. But with the DAO my head felt clear and I did not have the normal slump period. At first I thought maybe it was a placebo effect because I desperately wanted this to be the answer for me but then my rosacea almost completely cleared up within a week of taking this supplement and I felt like I could actually think again. I highly recommend this supplement! I am going to have my DAO levels tested soon but am fairly certain what they are going to say. Hopefully, the testing will direct me to how much I need to be taking. This supplement works so good for me!! I do want to add that this pill is not a free ticket to eat whatever you want. I cannot have most chocolate (cake, candy, etc) or any type of tomato sauce/soup. I’ll still break out in a rash. That being said, my rosacea and brain fog has improved significantly with this supplement and I’m so thankful! Read more

Muy bueno. Lo único que me ha quitado la alergia a la cerveza y a otras cosas. Read more

Thank goodness for these enzymes! I have terrible histamine intolerance. I pop one of these 5-10 minutes before my meal and I feel comfortable the rest of the day. I don’t know where I’d be without these. Love the high amount of DAO in this product. I will be buying this brand and only this brand from now on! Read more

Tengo un problema de disbiosis con histaminosis y el doctor recomendó tomar DAO. El producto llegó el mismo día que lo pedí y en perfecto estado. La caja es funcional, se abre y cierra de manera práctica. Sobre sus efectos, no puedo asegurar nada porque tengo múltiples síntomas; sin embargo, últimamente me he sentido mejor, sin dermatitis ni picazón. Read more

I am kind of stunned at how this product has helped me... I bought it months ago and never really applied it to my routines. Then, just the other day, after years of rashes and puffy eyes, IBS, I thought to myself "hey, what if I just take this before I eat anything." And I did that - and all of those problems vanished. I'm not kidding. I haven't had a rash since I started... and rashes were just a constant part of my life since childhood. Same for the rest, but the rashes in particular were so pervasive. Anyways, definitely give it a try if you struggle with histamine intolerance. Oh and I'm so much less puffy and bloated. My jawline and neck are more defined and also my waistline. Inflammation is insidious. This products helps. Read more

I have MCAS and unfortunately this triggered me. I was more nauseous and experienced higher heart rate with it. Legumes are high histamine and this may not be suitable for those with histamine toxicity / overload. Read more