High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues. Read more

Excellent product for MTHFR genetic disorder Read more

Perfect love this supplement!! Helps with fatigue. Read more

Caro pero bueno Read more

Dr recommended for my MTHFR gene mutation. No odor, not taste, no after taste. No stomach issues. Hope to see the benefit in raising my folate and lowering my homocysteine and thereby lowering a risk of heart attack. . Read more

I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months. Read more

Recently I found out I’m anemic and distant to go on medication so I did my research and found this to have all the things I need. Read more

I was having terrible muscle pains and went to my doctor. Blood work was done and it was found that I was severely deficient in the B vitamins (malabsorption issues in my digestive system). I did the injection of B vitamins in the doctor's office but needed to go on supplements to correct the deficiency long-term. I bought these and take two tablets, three times a day. I am now in to my second refill and it is four months later. The muscle pain has gone away, so has the numbness in my feet. I also feel like I have more energy. Read more

I'm a big believer in investing in high-quality supplements, and Thorne Research is one of the brands I trust most. Their Methyl-Guard Plus is a great option for anyone looking to support their methylation pathways, especially if they have the MTHFR gene mutation. I've been using Methyl-Guard Plus for a few months now, and I've noticed a significant improvement in my energy levels and overall well-being. I also appreciate that it doesn't cause any stomach upset, which is a common problem with other B-vitamin supplements. If you're looking for a high-quality, effective B-vitamin supplement, I highly recommend Thorne Research's Methyl-Guard Plus. Read more

I never write reviews for supplements. I started taking this because I started using an NAD+ patch. They recommend taking a menthylation supplement. (I'd never even heard of it). I took 3 tablets in the morning before my patch. Within 30 or 45 minutes, I immediately felt great, energetic. I can't even explain it. I hadn't changed anything else. I thought , "no way". I decided to take it the next day as well. Same thing! More energy, clear head, sort of, maybe happier. I can't believe. I've never a supplement do that for me. I have taken everything. I am menopausal and take HT (Evamist and progesterone 200mg). But this is the first thing I have taken to truly have an immediate impact. I can't say you will have the same results. Like I mentioned, I bought for a completely different reason. I'm thrilled with how it makes me feel. It's been 4 days now. It's wonderful. Read more

Only 5 days of taking it but I feel like it’s doing me good Read more

I am using this and have had no side effects or issues. Waiting for updated blood work to find how effective it is. I have used many Thorne products and have always enjoyed them. Read more

Love Thorne products, great quality 👌 Read more